Publications

• Wang M*, Brandt LTL, Wang X, Russell H, Mitchell E, Kamimae-Lanning AN, Brown JM, Dingler FA, Garaycoechea JI, Isobe T, Kingston SJ, Muxin G, Vassiliou GS, Wilson NK, Gottgens B, Patel KJ* (2023). Aldehyde genotoxic stress prematurely ages hematopoietic stem cells in a p53-driven manner. Molecular Cell, 2023 83:1-17 . *Co- corresponding authors.

• Wang M (2023). Targeting leukemia with a metabolic genotoxin. Blood. 2023 May 11;141(19):2293-2295.

• Wang M, Dingler FA, Patel KJ (2022). Genotoxic aldehydes in the hematopoietic system. Blood, 2022 Apr 7;139(14):2119-2129. doi: 10.1182/blood.2019004316.

• Dingler FA*, Wang M*, Mu A*,...Takata M, Patel KJ. (2020). Two aldehyde clearance systems are essential to prevent lethal formaldehyde accumulation in mice and humans. Molecular Cell, 80(6):996- 1012 *Joint authors.

• Wang M, Wang W, Abeywardane A, et al. (2015). Autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation: analysis of 533 adult patients transplanted at King’s College Hospital, Biology of Blood and Marrow Transplantation, 21(1):60-6.

• Wang M, Medeiros BC, Erba HP, Deangelo, DJ, Giles FJ, Swords RT (2011). Targeting protein neddylation: a novel therapeutic strategy for the treatment of cancer. Expert Opin Ther Targets 15, 253- 64.

• Wang M, Rada C and Neuberger MS (2011). A high throughput assay for DNA deaminases. Methods in Molecular Biology 718, 171-84.

• Wang M, Rada C and Neuberger MS (2010). Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID. The Journal of Experimental Medicine 207, 141-153.

• Wang M, Yang Z, Rada C and Neuberger MS (2009). AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity. Nature Structural & Molecular Biology 16, 769-776.

Contributing author:

• Wit N, Gogola E, West JA, Vornbäumen T, Seear RV, Bailey PSJ, Burgos-Barragan G, Wang M, Krawczyk P, Huberts DHEW, Gergely F, Matheson NJ, Kaser A, Nathan JA, Patel KJ (2023). A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production. Science Advances. 2023 May 19;9(20):eadg2235.

• Wu RA, Semlow DR, Kamimae-Lanning AN, Kochenova OV, Chistol G, Hodskinson MR, Amunugama R, Sparks JL, Wang M, Deng L, Mimoso CA, Low E, Patel KJ, Walter JC (2019). TRAIP is a master regulator of DNA interstrand crosslink repair. Nature. 2019 Mar;567(7747):267-272.

• Kollmann K, Warsch W, Gonzalez-Arias C, Avezov E, Milburn J, Li J, Nice F, Dimitropoulou D, Biddie S, Wang M, Poynton E, Anand S, McDermott U, Huntly B, Green A (2017). A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation. Leukemia Apr;31(4):934-944.

• Eskiocak U, Ramesh V, Gill JG, Zhao Z, Yuan SW, Wang M, Vandergriff T, Shackleton M, Quintana E, Johnson TM, DeBerardinis RJ, Morrison SJ (2016). Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma. Nature Communications 7:12336. doi: 10.1038/ncomms12336

• Rajendra E, Oestergaard VH, Langevin F, Wang M, Dornan GL, Patel KJ and Passmore LA (2014). The Genetic and Biochemical Basis of FANCD2 Monoubiquitination. Molecular Cell 54, 858-69.

Under revision:

• The molecular basis ofhaematological malignancies. Postgraduate Haematology, Wang M, Bolli N, Vassiliou G. Under revision